Lilly再出手，5.75億美元收購(gòu)腫瘤藥企業(yè)AurKa Pharma，獲得Aurora激酶抑制劑AK-01

2018-05-15 13:30:46


#LLY


正在布局抗腫瘤藥產(chǎn)品線的Lilly繼續(xù)發(fā)力

繼收購(gòu)Armo BioSciences之后

今日又宣布收購(gòu)AurKa Pharma

1.1億美元首付款

外加4.65億美元的里程碑款項(xiàng)

以及一定的銷(xiāo)售額分成

AurKa Pharma

2016年成立于加拿大蒙特利爾

TVM Capital Life Science Venture Capital第十二個(gè)投資項(xiàng)目

成立之初

正是旨在開(kāi)發(fā)Lilly旗下抗腫瘤活性化合物

也是此次看中的為Aurora激酶抑制劑AK-01

目前處于臨床I期研究中


Aurora激酶主要參與調(diào)節(jié)中心體和微管的功能

以保證染色體的精確分離和胞質(zhì)的有效分離

通常都在G2-M期達(dá)到高峰

調(diào)節(jié)著細(xì)胞周期中G2-M轉(zhuǎn)換

是調(diào)節(jié)M期進(jìn)展的關(guān)鍵因子



Aurora激酶由3個(gè)亞群組組成

Aurora-A、Aurora-B和Aurora-C

此時(shí)的過(guò)表達(dá)則導(dǎo)致遺傳的不穩(wěn)定性

造成細(xì)胞多倍體誘發(fā)惡性腫瘤

AurKa旗下的AK-01對(duì)Aurora-A有高度選擇性

臨床I期試驗(yàn)也證明了潛在的臨床收益

后續(xù)臨床將繼續(xù)評(píng)估臨床收益與風(fēng)險(xiǎn)的結(jié)果


Darren Carroll
Senior vice president of corporate business development at Lilly
“

The acquisition of AurKa Pharma supports Lilly's external innovation strategy, in which we seek to partner with leading life science venture capital firms in order to identify, support and access promising innovation in areas of unmet medical need. We are excited with the value TVM created for this compound through its early-Phase studies, and we look forward to more opportunities in the future.

”


Luc Marengere, Ph.D.
Managing Partner at TVM Capital Life Science
“

Through the unique healthcare venture capital model pioneered by TVM Capital Life Science, companies such as AurKa have been established to more quickly and efficiently bring promising compounds to clinical proof-of-concept. We are pleased that the scientific advances made by AurKa could contribute to the development of AK-01 and hopefully help deliver a potential new medicine for cancer patients.

”




Takeda在2015年終止了Aurora A抑制劑Alisertib

用于復(fù)發(fā)或難治性外周T細(xì)胞淋巴瘤III期臨床研究

但SCLC二線臨床II期研究還在等待

而AK-01此前的臨床I期研究中

選擇的是小細(xì)胞肺癌、乳腺癌和頭頸癌適應(yīng)癥的二線用藥

Lilly這一步棋走的有點(diǎn)意思

當(dāng)然這個(gè)收購(gòu)之路還將繼續(xù)

4-5筆剛完成2筆